Turmeric and Breast Cancer
I LOVE Turmeric... In fact, I have a teaspoon of the dried powder every day in my drinking water, I have a teaspoon in my oats, and I try to include it in as many of my meals as possible.
Why you may ask? Because value-for-money, Turmeric is one of the cheapest, most readily available and most powerful antioxidants and anti-inflammatory agents available.
You just have to look at the colour to see the potency of turmeric for your health. Turmeric is also one of the most well-studied natural substances, with over 1500 clinical studies showing a range of benefits:
- Supports your antioxidant protection against free radicals
- Helps promote healthy skin
- Supports overall eye health
- Provides immune system support
- Aids your skeletal system and joint health
- Encourages healthy liver function
- Helps maintain healthy cells with support against free radicals
- Balances the health of your digestive system
- Aids in support of healthy blood and circulatory system
- Helps maintain normal cholesterol levels to support your cardiovascular system
- Assists your neurological system's healthy response to stress
- Promotes a healthy female reproductive system and prevents breast cancer
- Helps maintain blood sugar levels already within the normal range
One of the most well-studied areas is in breast cancer treatment and prevention. Below are some of the study extracts to show you how effective it can be. The only caution is to watch you don't spill any on your favourite top - but apart from that, turmeric is one of the cheapest and best ways to protect and build your health.
Research & Study Topic Types
- In Vitro Study: 50
- Animal Study: 11
Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells. (GMI Summary)
Pubmed Data : Mol Carcinog. 2012 Jan 30. Epub 2012 Jan 30. PMID: 22290509
Article Published Date: Jan 30, 2012
Authors: Guang Yan, Kimmer Graham, Susan Lanza-Jacoby
Study Type: In Vitro Study
Additional Links:
Substances: Curcumin : CK(2727) : AC(1534)
Diseases: Breast Cancer: CK(2372) : AC(660)
Pharmacological Actions: Chemosensitizer : CK(197) : AC(159)
Additional Keywords: Drug Synergy : CK(327) : AC(147)
Curcumin induces programmed cell death in a murine mammary gland cells. (GMI Summary)
Pubmed Data: Eur J Pharmacol. 2011 Oct 1 ;668(1-2):127-32. Epub 2011 Jul 8. PMID: 21762689
Article Published Date : Oct 01, 2011
Authors: Abdelazim Ibrahim, Abdelmoniem El-Meligy, Gina Lungu, Hamdy Fetaih, Amina Dessouki, George Stoica, Rola Barhoumi
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions: Antineoplastic Agents: CK(877) : AC(496), Apoptotic: CK(1539) : AC(1155), Bcl-2 protein down-regulation : CK(49) : AC(38)
Curcumin decreases survival of liver and breast cancer cells. (GMI Summary)
Pubmed Data : Strahlenther Onkol. 2011 Jul ;187(7):393-400. Epub 2011 Jun 27. PMID: 21713389
Article Published Date: Jul 01, 2011
Authors: Mareike Ströfer, Wolfgang Jelkmann, Reinhard Depping
Study Type: In Vitro Study
Additional Links:
Substances: Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Hypoxia : CK(100) : AC(41), Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), Apoptotic : CK(1539) : AC(1155),Radiosensitizer : CK(52) : AC(29)
Curcumin inhibits telomerase activity in breast cancer cells - GMI Summary
Pubmed Data: J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 12104041
Article Published Date: Feb 01, 2011
Authors: Cheppail Ramachandran, Hugo B Fonseca, Perseus Jhabvala, Enrique A Escalon, Steven J Melnick
Study Type: In Vitro Study
Additional Links:
Substances: Curcumin : CK(2727) : AC(1534)
Diseases: Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions: Enzyme Inhibitors : CK(372) : AC(208), Telomerase Inhibitor : CK(41) : AC(22)
Curcumin reduces the expression of malignancy-associated Bcl-2 in breast cancer cells (GMI Summary)
Pubmed Data : Med Oncol. 2010 Dec;27(4):1114-8. Epub 2009 Nov 12. PMID: 19908170
Article Published Date : Dec 01, 2010
Authors : Jie Yang, Yunxin Cao, Jifeng Sun, Yong Zhang
Study Type: In Vitro Study
Additional Links:
Substances: Curcumin : CK(2727) : AC(1534)
Diseases: Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions: Bcl-2 protein down-regulation : CK(49) : AC(38)
Curcuminoids inhibit breast cancer cell proliferation. (GMI Summary)
Pubmed Data: Pharmacol Res. 2010 Nov 25. Epub 2010 Nov 25. PMID: 9714342
Article Published Date: Nov 25, 2010
Authors: A Simon, D P Allais, J L Duroux, J P Basly, S Durand-Fontanier, C Delage Study Type: In Vitro Study
Additional Links:
Substances: Curcumin : CK(2727) : AC(1534)
Diseases: Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions: Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1061) : AC(775), Cell cycle arrest : CK(390) : AC(319)
Curcumin suppresses breast cancer cells growth. (GMI Summary)
Pubmed Data : FEBS J. 2010 Aug;277(16):3437-48. Epub 2010 Jul 14. PMID: 20646066
Article Published Date: Aug 01, 2010
Authors: Mithu Banerjee, Parminder Singh, Dulal Panda
Study Type: In Vitro Study
Additional Links:
Substances: Curcumin : CK(2727) : AC(1534)
Diseases: Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions: Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775), Apoptotic : CK(1539) : AC(1155), Cell cycle arrest : CK(390) : AC(319)
Preventive compounds curcumin and piperine are capable of targeting breast stem cells. (GMI Summary)
Pubmed Data: Breast Cancer Res Treat. 2010 Aug ;122(3):777-85. Epub 2009 Nov 7. PMID:19898931
Article Published Date: Aug 01, 2010
Authors: Madhuri Kakarala, Dean E Brenner, Hasan Korkaya, Connie Cheng, Karim Tazi, Christophe Ginestier, Suling Liu, Gabriela Dontu, Max S Wicha
Study Type: In Vitro Study
Additional Links:
Substances: Curcumin : CK(2727) : AC(1534), Piperidines : CK(45) : AC(17) Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Stem Cells : CK(1015) : AC(53) Pharmacological Actions : Antiproliferative : CK(1061) : AC(775)
Additional Keywords : Cancer Stem Cells : CK(32) : AC(26), Selective Cytotoxicity : CK(60) : AC(42)
Curcumin exhibits anti-proliferative effects of curcumin against breast cancer. (GMI Summary)
Pubmed Data : Eur J Pharmacol. 2010 Jul 10;637(1-3):16-21. Epub 2010 Apr 10. PMID: 20385124
Article Published Date : Jul 10, 2010
Authors : Wen-Feng Hua, Yong-Shui Fu, Yi-Ji Liao, Wen-Jie Xia, Yang-Chao Chen, Yi-Xin Zeng, Hsiang-Fu Kung, Dan Xie
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), Cell cycle arrest : CK(390) : AC(319), Chemopreventive : CK(1528) : AC(382)
Curcumoids inhibit matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells. (GMI Summary)
Pubmed Data : Arch Pharm Res. 2010 Jul;33(7):989-98. Epub 2010 Jul 27. PMID: 20661707
Article Published Date : Jul 01, 2010
Authors : Mathanaporn Boonrao, Supachai Yodkeeree, Chadarat Ampasavate, Songyot Anuchapreeda, Pornngarm Limtrakul
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534), Turmeric : CK(3100) : AC(1597)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(26) : AC(6), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)
Curcumin bound to phosphatidylcholine is superior to plain curcumin in combatting mammary gland tumor cell proliferation. (GMI Summary)
Pubmed Data : In Vivo. 2010 Jul-Aug;24(4):401-8. PMID: 20668306
Article Published Date : Jul 01, 2010
Authors : Abdelazim Ibrahim, Abdelmouneim El-Meligy, Hamdy Fetaih, Amina Dessouki, George Stoica, Rola Barhoumi
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534), Phosphatidylcholine : CK(101) : AC(22)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Curcumin works synergistically with a PI3K inhibitor to induce cell death in breast cancer cells. (GMI Summary)
Pubmed Data : Biochem Biophys Res Commun. 2010 Apr 9;394(3):476-81. Epub 2010 Feb 6. PMID:20138829
Article Published Date : Apr 09, 2010
Authors : Jaleel Kizhakkayil, Faisal Thayyullathil, Shahanas Chathoth, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadari
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1539) : AC(1155), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)
Additional Keywords : Drug Synergy : CK(327) : AC(147)
Curcumin inhibits invasive ductal carcinoma of the breast in the cell model.(GMI Summary)
Pubmed Data : Chem Biol Interact. 2010 Feb 12;183(3):455-61. Epub 2009 Nov 26. PMID:19944674
Article Published Date : Feb 12, 2010
Authors : Chandra P Prasad, Gayatri Rath, Sandeep Mathur, Dinesh Bhatnagar, Ranju Ralhan
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Ductal Carcinoma: Invasive : CK(63) : AC(5)
Pharmacological Actions : Anti-Proliferative : CK(55) : AC(49), Antineoplastic Agents : CK(877) : AC(496), Maspin (Protease Inhibitor) Up-Regulation : CK(1) : AC(1), Protease Inhibitors : CK(15) : AC(6), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)
Demethoxycurcumin suppresses migration and invasion of human breast cancer cell line. (GMI Summary)
Pubmed Data : Eur J Pharmacol. 2010 Feb 10;627(1-3):8-15. Epub 2009 Oct 7. PMID: 19818349
Article Published Date : Feb 10, 2010
Authors : Supachai Yodkeeree, Chadarat Ampasavate, Bokyung Sung, Bharat B Aggarwal, Pornngarm Limtrakul
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534), Demethoxycurcumin : CK(9) : AC(7), Turmeric : CK(3100) : AC(1597)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), NF-kappaB Inhibitor : CK(595) : AC(401)
Curcumin has anti-breast cancer activity. (GMI Summary)
Pubmed Data : J Exp Ther Oncol. 2010;8(3):261-6. PMID: 20734924
Article Published Date : Jan 01, 2010
Authors : Analía Quiroga, Patricia L Quiroga, Estefanía Martínez, Elio A Soria, Mirta A Valentich
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1539) : AC(1155), Enzyme Inhibitors : CK(372) : AC(208)
Curcumin reduced the side effects of mitomycin C in the treatment of breast cancer. (GMI Summary)
Pubmed Data : Cancer Sci. 2009 Nov;100(11):2040-5. Epub 2009 Jul 23. PMID: 19703194
Article Published Date : Nov 01, 2009
Authors : Qian-Mei Zhou, Hui Zhang, Yi-Yu Lu, Xiu-Feng Wang, Shi-Bing Su
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Chemotherapy Induced Myelotoxicity : CK(48) : AC(13), Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Mitomycin-C : CK(6) : AC(4), DNA damage : CK(711) : AC(293)
Pharmacological Actions : Renoprotective : CK(191) : AC(90)
Additional Keywords : Drug: Mitomycin : CK(4) : AC(3), Drug Synergy : CK(327) : AC(147)
Curcumin suppresses human breast cancer cell growth.(GMI Summary)
Pubmed Data : Chem Biol Interact. 2009 Oct 7;181(2):263-71. Epub 2009 Jun 30. PMID: 19573523
Article Published Date : Oct 07, 2009
Authors : Chandra P Prasad, Gayatri Rath, Sandeep Mathur, Dinesh Bhatnagar, Ranju Ralhan
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Curcumin may inhibit breast cancer cell proliferation through down-regulating the NFkappaB inducing genes. (GMI Summary)
Pubmed Data : Phytomedicine. 2009 Oct;16(10):916-22. Epub 2009 Jun 12. PMID: 19524420
Article Published Date : Oct 01, 2009
Authors : Q Liu, Wings T Y Loo, S C W Sze, Y Tong
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Plant Extracts : CK(3775) : AC(1248)
Curcumin induces programmed cell death in triple negative breast cancer cell lines. (GMI Summary)
Pubmed Data : Breast Cancer. 2009 Sep 2;3:61-75. PMID: 19809577
Article Published Date : Sep 02, 2009
Authors : Danica L Rowe, Tuba Ozbay, Ruth M O'Regan, Rita Nahta
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Breast Cancer: Triple Negative : CK(61) : AC(13)
Pharmacological Actions : Apoptotic : CK(1539) : AC(1155)
Curcumin works synergistically with paclitaxel to inhibit breast cancer in a mouse model. (GMI Summary)
Pubmed Data : Breast J. 2009 May-Jun;15(3):223-9. PMID: 19645775
Article Published Date : May 01, 2009
Authors : Hee Joon Kang, Sang Hun Lee, Janet E Price, Lee Su Kim
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775), Apoptotic : CK(1539) : AC(1155), NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Curcumin has anti-breast cancer activity related to the activities of protein kinases on cell signal pathway. - GMI Summary
Pubmed Data : Zhong Yao Cai. 2009 May;32(5):728-32. PMID: 19771847
Article Published Date : May 01, 2009
Authors : Qian-Mei Zhou, Shi-Bing Su, Hui Zhang, Yi-Yu Lu
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), Enzyme Inhibitors : CK(372) : AC(208), NF-kappaB Inhibitor : CK(595) : AC(401), Protein Kinase Inhibitors : CK(15) : AC(11)
Curcumin inhibits the proliferation and migration of breast cancer cells.(GMI Summary)
Pubmed Data : Int J Mol Med. 2009 Apr;23(4):469-75. PMID: 19288022
Article Published Date : Apr 01, 2009
Authors : Tsung-Lang Chiu, Chin-Cheng Su
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775), Cell cycle arrest : CK(390) : AC(319)
Curcumin inhibits the growth of hormone-independent and multi-drug resistant breast cancer cells.(GMI Summary)
Pubmed Data : Ann N Y Acad Sci. 2009 Feb;1155:278-83. PMID: 19250217
Article Published Date : Feb 01, 2009
Authors : Manuela Labbozzetta, Monica Notarbartolo, Paola Poma, Annamaria Maurici, Luigi Inguglia, Paolo Marchetti, Michele Rizzi, Riccardo Baruchello, Daniele Simoni, Natale D'Alessandro
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancers: Multi-Drug Resistant : CK(92) : AC(73)
Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland. (GMI Summary)
Pubmed Data : J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339
Article Published Date : Jan 01, 2009
Authors : M Onoda, H Inano
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3723) : AC(1318), Nitric Oxide Inhibitor : CK(108) : AC(57)
Combined xanthorrhizol-curcumin exhibits synergistic growth inhibitory activity via programmed cell death in human breast cancer cells. (GMI Summary)
Pubmed Data : Cancer Cell Int. 2009;9:1. Epub 2009 Jan 2. PMID: 19118501
Article Published Date : Jan 01, 2009
Authors : Yew Hoong Cheah, Fariza Juliana Nordin, Rozie Sarip, Thiam Tsui Tee, Hawariah Lope Pihie Azimahtol, Hasnah M Sirat, Badrul Amini Abd Rashid, Noor Rain Abdullah, Zakiah Ismail
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Apoptotic : CK(1539) : AC(1155)
Curcumin inhibits integrin (alpha6beta4)-dependent breast cancer cell motility and invasion. (GMI Summary)
Pubmed Data : Cancer Prev Res (Phila). 2008 Oct;1(5):385-91. PMID: 19138983
Article Published Date : Oct 01, 2008
Authors : Hong Im Kim, Huang Huang, Satish Cheepala, Shile Huang, Jun Chung Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Apoptotic : CK(1539) : AC(1155),Enzyme Inhibitors : CK(372) : AC(208)
Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. (GMI Summary)
Pubmed Data : Cancer Res. 2008 Jul 1;68(13):5185-92. PMID: 18593918
Article Published Date : Jul 01, 2008
Authors : Madhusudhanan Narasimhan, Sudhakar Ammanamanchi
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), NF-kappaB Inhibitor : CK(595) : AC(401)
Curcumin prevents progestin-induced breast cancer cell promotion. (GMI Summary)
Pubmed Data : Menopause. 2008 May-Jun;15(3):570-4. PMID: 18467956
Article Published Date : May 01, 2008
Authors : Candace E Carroll, Mark R Ellersieck, Salman M Hyder
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Drug-Induced Toxicity: Progestin : CK(1) : AC(1)
Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
The combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo. (GMI Summary)
Pubmed Data : Int J Cancer. 2008 May 1;122(9):1966-71. PMID: 18098290
Article Published Date : May 01, 2008
Authors : Tiffany J Somers-Edgar, Marissa J Scandlyn, Emma C Stuart, Martin J Le Nedelec, Sophie P Valentine, Rhonda J Rosengren
Study Type : Animal Study
Additional Links:
Substances : Catechin : CK(403) : AC(130), Curcumin : CK(2727) : AC(1534) Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), Estrogen Receptor Modulators : CK(28) : AC(19), Vascular Endothelial Growth Factor Inhibitors : CK(13) : AC(8)
Additional Keywords : ER Alpha-Breast Cancer : CK(2) : AC(1)
Curcumin exhibits anti-metastatic properties in breast cancer cells. (GMI Summary)
Pubmed Data : Carcinogenesis. 2008 Apr;29(4):779-89. Epub 2007 Nov 13. PMID: 17999991
Article Published Date : Apr 01, 2008
Authors : Beatrice E Bachmeier, Isabelle V Mohrenz, Valentina Mirisola, Erwin Schleicher, Francesco Romeo, Clara Höhneke, Marianne Jochum, Andreas G Nerlich, Ulrich Pfeffer
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antioxidants : CK(3723) : AC(1318), NF-kappaB Inhibitor : CK(595) : AC(401)
Various plant substances inhibit chemically-induced mammary gland tumor promotion. (GMI Summary)
Pubmed Data : Nutr Cancer. 2008 Mar-Apr;60(2):227-34. PMID: 1905902
Article Published Date : Mar 01, 2008
Authors : R G Mehta, R C Moon
Study Type : In Vitro Study
Additional Links:
Substances : Beta Sitosterol : CK(43) : AC(14), Curcumin : CK(2727) : AC(1534), D-Limonene : CK(20) : AC(8), DHEA (Dehydroepiandrosterone) : CK(230) : AC(37), Silymarin : CK(36) : AC(8)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Chemopreventive : CK(1528) : AC(382)
Curcumin exhibits anti-breast cancer properties. (GMI Summary)
Pubmed Data : Biochim Biophys Acta. 2007 Jul;1773(7):1116-23. Epub 2007 May 1. PMID:17555831
Article Published Date : Jul 01, 2007
Authors : Huang-Ge Zhang, Helen Kim, Cunren Liu, Shaohua Yu, Jianhua Wang, William E Grizzle, Robert P Kimberly, Stephen Barnes
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
The anti-breast cancer activity of curcumin may be due in part to its down-regulation of insulin-like growth factor. (GMI Summary)
Pubmed Data : Life Sci. 2007 May 16;80(23):2161-9. Epub 2007 Apr 21. PMID: 17499312
Article Published Date : May 16, 2007
Authors : Yanqiu Xia, Liji Jin, Bin Zhang, Hongyu Xue, Qiujuan Li, Yongping Xu
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Insulin-like Growth Factor (IGF): Elevated : CK(33) : AC(6)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775), Apoptotic : CK(1539) : AC(1155), Cell cycle arrest : CK(390) : AC(319), Insulin-Like Growth Factor Inhibition/Downregulation : CK(66) : AC(16)
Additional Keywords : Drug Synergy : CK(327) : AC(147)
Apple and curcumin extracts contain phytochemicals which inhibit cellular processes associated with breast cancer cell resistance to chemotherapy. (GMI Summary)
Pubmed Data : J Agric Food Chem. 2007 Apr 18;55(8):3167-73. Epub 2007 Mar 21. PMID:17373813
Article Published Date : Apr 18, 2007
Authors : Hyungeun Yoon, Rui Hai Liu
Study Type : In Vitro Study
Additional Links:
Substances : Apples : CK(179) : AC(57), Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)
Curcumin exhibits chemopreventive properties in hematogenous breast cancer metastases in immunodeficient mice. - GMI Summary
Pubmed Data : Cell Physiol Biochem. 2007;19(1-4):137-52. PMID: 17310108
Article Published Date : Jan 01, 2007
Authors : Beatrice Bachmeier, Andreas G Nerlich, Cristina M Iancu, Michele Cilli, Erwin Schleicher, Roberta Vené, Raffaella Dell'Eva, Marianne Jochum, Adriana Albini, Ulrich Pfeffer
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135), Immune Disorders: Low Immune Function : CK(488) : AC(115), Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1539) : AC(1155), NF-kappaB Inhibitor : CK(595) : AC(401)
Curcumin inhibits the growth of breast cancer through the manipulation of the arachidonate metabolism. (GMI Summary)
Pubmed Data : BMC Cancer. 2007;7:138. Epub 2007 Jul 25. PMID: 17651499 Article Published Date : Jan 01, 2007
Authors : Rasha Hammamieh, Dena Sumaida, XiaoYan Zhang, Rina Das, Marti Jett Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancers: Drug Resistant : CK(225) : AC(147)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Cyclooxygenase Inhibitors : CK(64) : AC(32), Lipoxygenase Inhibitors : CK(26) : AC(15)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)
Curcumin inhibits cyclooxygenase and matrix metalloproteinase-8 expression associated with breast cancer progression. (GMI Summary)
Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1612-20. PMID: 16356124
Article Published Date : Nov 01, 2005
Authors : Ki Won Lee, Jung-Hwan Kim, Hyong Joo Lee, Young-Joon Surh Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30), NF-kappaB Inhibitor : CK(595) : AC(401)
Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model.
- GMI Summary
Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823 Article Published Date : Oct 15, 2005
Authors : Bharat B Aggarwal, Shishir Shishodia, Yasunari Takada, Sanjeev Banerjee, Robert A Newman, Carlos E Bueso-Ramos, Janet E Price
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Breast Cancer: Lung Metastasis : CK(13) : AC(7),Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1539) : AC(1155), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Drug: Paclitaxel : CK(36) : AC(13), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Curcumin induces programmed cell death in breast cancer cells. (GMI Summary)
Pubmed Data : Anticancer Res. 2005 Sep-Oct;25(5):3293-302. PMID: 16101141 Article Published Date : Sep 01, 2005
Authors : Cheppail Ramachandran, Sonia Rodriguez, Reshma Ramachandran, P K Raveendran Nair, Hugo Fonseca, Ziad Khatib, Enrique Escalon, Steven J Melnick Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1539) : AC(1155)
Curcumin inhibits programmed cell death in breast cancer cells. (GMI Summary)
Pubmed Data : J Biol Chem. 2005 May 20;280(20):20059-68. Epub 2005 Feb 28. PMID: 15738001
Article Published Date : May 20, 2005
Authors : Tathagata Choudhuri, Suman Pal, Tanya Das, Gaurisankar Sa
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1539) : AC(1155), Cell cycle arrest : CK(390) : AC(319), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)
Curcumin induces programmed cell death and growth inhibition in breast cancer cells. (GMI Summary)
Pubmed Data : Cochrane Database Syst Rev. 2005(4):CD004649. Epub 2005 Oct 19. PMID:10445426
Article Published Date : Jan 01, 2005
Authors : C Ramachandran, W You
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), Apoptotic : CK(1539) : AC(1155)
Curcumin induces programmed cell death in human breast cancer cells. (GMI Summary)
Pubmed Data : Biochem Pharmacol. 2003 Feb 1;65(3):361-76. PMID: 12527329 Article Published Date : Feb 01, 2003
Authors : Matthew S Squires, E Ann Hudson, Lynne Howells, Stewart Sale, Catherine E Houghton, J Louise Jones, Louise H Fox, Martin Dickens, Sally A Prigent, Margaret M Manson
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), Apoptotic : CK(1539) : AC(1155),Enzyme Inhibitors : CK(372) : AC(208)
Curcumin induces programmed cell death in breast cancer cells. (GMI Summary)
Pubmed Data : Mutat Res. 2002 Jun 27;518(1):71-84. PMID: 12063069
Article Published Date : Jun 27, 2002
Authors : Jon M Holy
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775), Apoptotic : CK(1539) : AC(1155),Cell cycle arrest : CK(390) : AC(319)
Curcumin exerts multiple suppressive effects on human breast carcinoma cells. (GMI Summary)
Pubmed Data : Int J Cancer. 2002 Mar 10;98(2):234-40. PMID: 11857414
Article Published Date : Mar 10, 2002
Authors : Zhi-Ming Shao, Zhen-Zhou Shen, Can-Hui Liu, Maryam R Sartippour, Vay Liang Go, David Heber, Mai Nguyen
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775)
Curcumin induces programmed cell death in breast cancer. (GMI Summary)
Pubmed Data : FEBS Lett. 2002 Feb 13;512(1-3):334-40. PMID: 11852106
Article Published Date : Feb 13, 2002
Authors : Tathagata Choudhuri, Suman Pal, Munna L Agwarwal, Tanya Das, Gaurisankar Sa
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Apoptotic : CK(1539) : AC(1155), Cell cycle arrest : CK(390) : AC(319),Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)
Curcumin prevents radiation-induced mammary tumors. (GMI Summary)
Pubmed Data : Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):212-23. PMID: 11777641
Article Published Date : Jan 01, 2002
Authors : Hiroshi Inano, Makoto Onoda
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Breast Cancer: Prevention : CK(525) : AC(73)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3723) : AC(1318), Enzyme Inhibitors : CK(372) : AC(208),Radioprotective : CK(458) : AC(183)
Curcumin induces programmed cell death in mouse breast cancer cells.(GMI Summary)
Pubmed Data : Biochem Biophys Res Commun. 2001 Nov 2;288(3):658-65. PMID: 11676493
Article Published Date : Nov 02, 2001
Authors : S Pal, T Choudhuri, S Chattopadhyay, A Bhattacharya, G K Datta, T Das, G Sa
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1539) : AC(1155), Bcl-2 protein down-regulation : CK(49) : AC(38), Cell cycle arrest : CK(390) : AC(319)
Curcumin inhibits the invasion and induces programmed cell death in human breast cancer cells. (GMI Summary)
Pubmed Data : Arch Pharm Res. 2001 Aug;24(4):349-54. PMID: 11534770
Article Published Date : Aug 01, 2001
Authors : M S Kim, H J Kang, A Moon
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Apoptotic : CK(1539) : AC(1155)
Curcumin has a potent preventive action against radiation-induced breast cancer initiation. (GMI Summary)
Pubmed Data : Carcinogenesis. 2000 Oct;21(10):1835-41. PMID: 11023541
Article Published Date : Oct 01, 2000
Authors : H Inano, M Onoda, N Inafuku, M Kubota, Y Kamada, T Osawa, H Kobayashi, K Wakabayashi
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Radioprotective : CK(458) : AC(183)
Curcumin exhibits anti-cancer, anti-inflammatory and antioxidant activities. (GMI Summary)
Pubmed Data : Phytomedicine. 2000 Jul;7(4):303-8. PMID: 10969724
Article Published Date : Jul 01, 2000
Authors : R S Ramsewak, D L DeWitt, M G Nair
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Colon Cancer : CK(895) : AC(233), Kidney Cancer : CK(120) : AC(17), Melanoma : CK(171) : AC(87)
Pharmacological Actions : Antioxidants : CK(3723) : AC(1318), Cyclooxygenase 1 Inhibitor : CK(22) : AC(18), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Cyclooxygenase Inhibitors : CK(64) : AC(32)
Curcumin inhibits tyrosine kinase activity associated breast cancer cell promotion. (GMI Summary)
Pubmed Data : Clin Cancer Res. 1999 Jul;5(7):1884-91. PMID: 10430096
Article Published Date : Jul 01, 1999
Authors : R L Hong, W H Spohn, M C Hung
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775), Enzyme Inhibitors : CK(372) : AC(208), Heat Shock Protein Inducer : CK(51) : AC(17)
Curcumin has a potent preventive activity during the DES-dependent promotion stage of radiation-induced mammary tumorigenesis. (GMI Summary)
Pubmed Data : Carcinogenesis. 1999 Jun;20(6):1011-8. PMID: 10357781
Article Published Date : Jun 01, 1999
Authors : H Inano, M Onoda, N Inafuku, M Kubota, Y Kamada, T Osawa, H Kobayashi, K Wakabayashi
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Radioprotective : CK(458) : AC(183)
Natural plant compounds may have preventive and therapeutic applications against the growth of breast tumors induced by environmental estrogens (GMI Summary)
Pubmed Data : Environ Health Perspect. 1998 Dec;106(12):807-12. PMID: 9831541
Article Published Date : Dec 01, 1998
Authors : S P Verma, B R Goldin, P S Lin
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534), Isoflavones : CK(627) : AC(124) Diseases : Breast Cancer : CK(2372) : AC(660), Estrogen Dominance : CK(106) : AC(37), Pesticide Toxicity : CK(147) : AC(45), Xenobiotic Exposures : CK(54) : AC(6)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775)
Curcumin exhibits anti-cancer properties in breast cancer cells. (GMI Summary)
Pubmed Data : Biochem Pharmacol. 1998 Jul 15;56(2):197-206. PMID: 9698073
Article Published Date : Jul 15, 1998
Authors : H P Ciolino, P J Daschner, T T Wang, G C Yeh
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)
Curcumin has a preventive effect on chemically-induced breast cancer. (GMI Summary)
Pubmed Data : Carcinogenesis. 1998 Jun;19(6):1039-43. PMID: 9667742
Article Published Date : Jun 01, 1998
Authors : K Singletary, C MacDonald, M Iovinelli, C Fisher, M Wallig Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), DNA damage : CK(711) : AC(293)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)
A curcumin-free water extract of turmeric prevents chemically-induced mammary cancer in rats. (GMI Summary)
Pubmed Data : Cancer Lett. 1998 Jan 16;123(1):35-40. PMID: 9461015
Article Published Date : Jan 16, 1998
Authors : S S Deshpande, A D Ingle, G B Maru Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534), Turmeric : CK(3100) : AC(1597) Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)
Additional Keywords : Plant Extracts : CK(3775) : AC(1248), Turmeric Versus Curcumin : CK(4) : AC(2)
Curcumin has antiproliferative effects against human breast tumor cell lines. (GMI Summary)
Pubmed Data : Anticancer Drugs. 1997 Jun;8(5):470-81. PMID: 9215611
Article Published Date : Jun 01, 1997
Authors : K Mehta, P Pantazis, T McQueen, B B Aggarwal
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Cancers: Drug Resistant : CK(225) : AC(147),Cancers: Multi-Drug Resistant : CK(92) : AC(73)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)
Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. (GMI Summary)
Pubmed Data : Biochem Biophys Res Commun. 1997 Apr 28;233(3):692-6. PMID: 9168916
Article Published Date : Apr 28, 1997
Authors : S P Verma, E Salamone, B Goldin
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)
Diseases : Breast Cancer : CK(2372) : AC(660), Pesticide Toxicity : CK(147) : AC(45)
Pharmacological Actions : Antiproliferative : CK(1061) : AC(775)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Curcumin prevents chemically-induced mammary cancer. (GMI Summary)
Pubmed Data : Cancer Lett. 1996 Jun 5;103(2):137-41. PMID: 8635149
Article Published Date : Jun 05, 1996
Authors : K Singletary, C MacDonald, M Wallig, C Fisher
Study Type : Animal Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), DNA damage : CK(711) : AC(293)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Curcuminoids have anti-tumor and antioxidant activity. (GMI Summary)
Pubmed Data : Cancer Lett. 1995 Jul 20;94(1):79-83. PMID: 7621448
Article Published Date : Jul 20, 1995
Authors : A J Ruby, G Kuttan, K D Babu, K N Rajasekharan, R Kuttan
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660), Oxidative Stress : CK(1975) : AC(710), Tumors : CK(199) : AC(110)
Pharmacological Actions : Anti-Tumor : CK(69) : AC(44), Antioxidants : CK(3723) : AC(1318)
Curcumin has anti-proliferative activity on human breast cancer cells. (GMI Summary)
Pubmed Data : Can Fam Physician. 1993 Nov;39:2362-7. PMID: 14642080
Article Published Date : Nov 01, 1993
Authors : Gen-hong Di, He-cheng Li, Zhen-zhou Shen, Zhi-min Shao
Study Type : In Vitro Study
Additional Links:
Substances : Curcumin : CK(2727) : AC(1534)
Diseases : Breast Cancer : CK(2372) : AC(660)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1061) : AC(775), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Vascular Endothelial Growth Factor Inhibitors : CK(13) : AC(8)
